Krystal Biotech (KRYS)

Healthcare · Biotechnology
$326.81 -2.40% on the day Market cap $9.2B 52-week range $179.19 to $382.54 Prices as of Oct 7, 2026

What the price implies

A reverse DCF: instead of guessing a fair value, it asks what growth today's price already assumes. How it works.

Free cash flow growth the price needs
17% a year for 10 years

At a market value of $9.2B, Krystal Biotech's free cash flow of $189M (fiscal 2025) would need to grow about 17% a year for the stock to be worth today's price. That is slower than the company has grown its free cash flow over the last 1 years.

Assumes a 9% discount rate and 3% growth after year 10, on free cash flow (operating cash flow minus capital spending) from Krystal Biotech's SEC filings. Change any assumption, or model revenue and margins instead, in the Modeling tab, or try your own numbers in the reverse DCF calculator.

Implied by the price16.6% a year
Free cash flow, last 1 years58.5% a year
Revenue, same period177.0% a year
Price to free cash flow48.6x

Fundamental grade

B

Five factors scored 1 to 9 from KRYS's latest numbers, weighted into one grade. It describes the business, not whether the stock is a buy.

Valuation2
Profitability8
Growth8
Financial health9
Cash efficiency9

Key numbers

P/E (trailing)41.8x
P/E (forward)44.9x
Price / free cash flow48.6x
EV / EBITDA35.5x
Price / sales20.9x
Price / book7.09x
Revenue growth+24.1%
Operating margin44.9%
Net margin54.8%
Return on equity17.8%
Dividend yield—
Debt / equity0.10x

Results from SEC filings

Fiscal years, from Krystal Biotech's 10-K filings. The deep dive has 15+ years, quarters and every line.

Fiscal year20212022202320242025
Revenue$0$0$51M$291M$389M
Net income-$70M-$140M$11M$89M$205M
Free cash flow-$116M-$154M-$101M$119M$189M
EPS (diluted)-$3.13-$5.49$0.39$3.00$6.84
Operating margin——-216.2%22.6%41.5%

Superinvestors who own KRYS

From each investor's latest 13F filing (what a 13F shows). 2 of the investors we track hold it.

InvestorLast quarterValue% of portfolioQuarter
Cliff Asness
AQR Capital Management
Trimmed $5M0.00%Q2 2026
Joel Greenblatt
Gotham Asset Management
Added $494,3210.00%Q2 2026

Insider buying

Open-market purchases by Krystal Biotech's executives and directors in the last 12 months, from SEC Form 4 filings. What insider buying tells you.

No open-market insider purchases of KRYS in the last 12 months. Most insider activity is selling and option exercises, which aren't shown here.

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In the full deep dive

DCF fair value per share
Yearly return (IRR) at today's price
Growth implied by revenue and margins
15+ years of statements and quarters

Questions

What growth does Krystal Biotech's stock price imply?

At a market value of $9.2B, Krystal Biotech would need its free cash flow to grow about 17% a year for 10 years (discounted at 9%, 3% growth after that) to be worth today's price. Over the last 1 years its free cash flow grew 59% a year.

Are Krystal Biotech insiders buying the stock?

No open-market insider purchases of KRYS in the last 12 months, according to SEC Form 4 filings.

Which superinvestors own Krystal Biotech?

2 of the superinvestors Investingly tracks hold KRYS in their latest 13F, including Cliff Asness, Joel Greenblatt.

Prices and ratios as of Oct 7, 2026; statements from SEC filings. Information only, not investment advice. Superinvestor holdings come from 13F filings, which are filed up to 45 days after each quarter ends.