Quality
Highest profit margin Healthcare stocks
Net income as a share of revenue, highest first. Companies worth over $1 billion.
Top of the list: HUTCHMED DRC (HCM) 83.3%; AnaptysBio (ANAB) 82.4%; Innoviva (INVA) 81.2%.
The median net margin across these 50 companies is 26.8%.
| # | Company | Net margin | Operating margin | Gross margin | P/E | Market cap |
|---|---|---|---|---|---|---|
| 1 | HUTCHMED DRCHCM | 83.3% | -7.1% | 38.7% | 27.1x | $2.3B |
| 2 | AnaptysBio IncANAB | 82.4% | 131.7% | — | — | $1.3B |
| 3 | Innoviva IncINVA | 81.2% | 37.0% | 72.2% | 3.26x | $1.5B |
| 4 | Ligand Pharmaceuticals IncorporatedLGND | 67.9% | 32.6% | — | 39.5x | $6.1B |
| 5 | TG Therapeutics IncTGTX | 55.2% | 17.1% | 82.4% | 17.1x | $7.5B |
| 6 | Krystal Biotech IncKRYS | 54.8% | 44.9% | 94.6% | 42.4x | $9.3B |
| 7 | United Therapeutics CorporationUTHR | 41.6% | 44.4% | 86.1% | 19.8x | $22.8B |
| 8 | Cronos Group IncCRON | 39.1% | -1.4% | 45.9% | 0.00x | $1.2B |
| 9 | Genmab ASGMAB | 36.4% | 31.1% | 95.4% | 27.2x | $22.0B |
| 10 | Exelixis IncEXEL | 35.3% | 39.9% | 96.5% | 18.8x | $14.3B |
| 11 | Vertex Pharmaceuticals IncVRTX | 35.0% | 38.0% | 86.0% | 28.8x | $123.0B |
| 12 | Eli Lilly and CompanyLLY | 33.5% | — | 83.4% | 43.0x | $1.08T |
| 13 | ACADIA Pharmaceuticals IncACAD | 33.4% | 7.6% | 91.1% | 8.64x | $3.3B |
| 14 | Novo Nordisk A/SNVO | 33.1% | 41.3% | 81.0% | 8.53x | $161.1B |
| 15 | ADMA Biologics IncADMA | 33.0% | 43.8% | 64.7% | 15.0x | $2.4B |
| 16 | Royalty Pharma PlcRPRX | 32.1% | 59.6% | — | 29.5x | $32.3B |
| 17 | Liquidia Technologies IncLQDA | 30.7% | 37.4% | — | 172.7x | $2.6B |
| 18 | argenx NV ADRARGX | 30.4% | 24.8% | 89.4% | 42.2x | $50.6B |
| 19 | Protagonist Therapeutics IncPTGX | 29.4% | 20.7% | — | — | $8.8B |
| 20 | Veeva Systems Inc Class AVEEV | 29.3% | 29.9% | 75.0% | 57.1x | $50.7B |
| 21 | Lakefront Biotherapeutics NVLKFT | 28.9% | 26.5% | 97.3% | 3.29x | $1.9B |
| 22 | Intuitive Surgical IncISRG | 28.4% | 31.3% | 66.7% | 52.8x | $153.4B |
| 23 | Regeneron Pharmaceuticals IncREGN | 27.9% | 24.7% | — | 16.0x | $68.5B |
| 24 | Zoetis IncZTS | 27.5% | — | 71.5% | 13.0x | $33.3B |
| 25 | ResMed IncRMD | 26.9% | 33.4% | 61.1% | 22.8x | $34.4B |
| 26 | Incyte CorporationINCY | 26.7% | 30.1% | 92.5% | 15.4x | $21.8B |
| 27 | Iradimed CoIRMD | 26.7% | 31.9% | 75.9% | 49.0x | $1.1B |
| 28 | Indivior PLC Ordinary SharesINDV | 26.6% | 31.6% | 82.1% | 17.9x | $4.1B |
| 29 | Doximity IncDOCS | 25.5% | 29.6% | 88.1% | 25.2x | $4.7B |
| 30 | IDEXX Laboratories IncIDXX | 25.0% | 32.0% | 62.5% | 39.3x | $42.2B |
| 31 | LeMaitre Vascular IncLMAT | 25.0% | 29.5% | 72.9% | 30.8x | $1.9B |
| 32 | Halozyme Therapeutics IncHALO | 24.9% | 35.9% | 82.4% | 37.1x | $12.6B |
| 33 | CareDx IncCDNA | 24.2% | 23.6% | — | — | $3.2B |
| 34 | Amgen IncAMGN | 22.9% | 30.0% | 69.5% | 28.0x | $217.3B |
| 35 | TransMedics Group IncTMDX | 22.7% | 12.2% | 58.7% | 19.7x | $3.0B |
| 36 | Mettler-Toledo International IncMTD | 21.9% | — | 60.3% | 38.9x | $33.4B |
| 37 | Johnson & JohnsonJNJ | 21.5% | — | 67.9% | 30.5x | $632.9B |
| 38 | Neurocrine Biosciences IncNBIX | 20.9% | 23.6% | 98.0% | 21.4x | $14.0B |
| 39 | Veracyte IncVCYT | 20.4% | 18.8% | 71.7% | 49.5x | $4.3B |
| 40 | Qiagen NVQGEN | 20.3% | 22.3% | 62.2% | 23.4x | $9.8B |
| 41 | DexCom IncDXCM | 20.1% | 22.9% | 62.5% | 41.2x | $39.6B |
| 42 | Agilent Technologies IncA | 19.5% | 22.2% | 53.8% | 37.2x | $47.8B |
| 43 | Harmony Biosciences HoldingsHRMY | 18.9% | 24.0% | 75.4% | 16.5x | $2.4B |
| 44 | Bristol-Myers Squibb CompanyBMY | 18.9% | 24.2% | 70.2% | 16.7x | $122.0B |
| 45 | Illumina IncILMN | 18.4% | 19.6% | 66.4% | 49.4x | $41.1B |
| 46 | Humana IncHUM | 18.3% | 39.6% | — | 46.9x | $52.8B |
| 47 | Lantheus Holdings IncLNTH | 17.7% | 19.4% | 60.1% | 23.0x | $6.3B |
| 48 | Medpace Holdings IncMEDP | 17.7% | 21.0% | — | 38.2x | $17.3B |
| 49 | GlaxoSmithKline PLC ADRGSK | 17.5% | 24.3% | 72.4% | 12.3x | $93.4B |
| 50 | Boston Scientific CorpBSX | 17.5% | 19.8% | 69.9% | 17.8x | $63.1B |
Ranked from each company's latest price and reported results. Companies need a page on Investingly (SEC statements on file). Open any company for its reverse DCF, insider buying and 13F holders.
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Questions
Which company ranks first on the highest profit margin healthcare stocks list?
HUTCHMED DRC (HCM), with a net margin of 83.3%, as of October 12, 2026.
How is this list built?
Net income as a share of revenue, highest first. Companies worth over $1 billion. It shows the top 50 and is rebuilt every day.
Prices and ratios as of Oct 11, 2026. Statements from SEC filings. Information only, not investment advice.