Quality
Highest return on equity Healthcare stocks
Net income as a share of shareholders' equity, for companies worth over $1 billion with debt under twice equity (heavy debt inflates ROE).
Top of the list: HUTCHMED DRC (HCM) 158.6%; TG Therapeutics (TGTX) 73.1%; Liquidia Technologies (LQDA) 71.0%.
The median roe across these 50 companies is 23.4%.
| # | Company | ROE | ROA | Debt/equity | Net margin | Market cap |
|---|---|---|---|---|---|---|
| 1 | HUTCHMED DRCHCM | 158.6% | 98.2% | 0.53x | 83.3% | $2.3B |
| 2 | TG Therapeutics IncTGTX | 73.1% | 26.9% | 1.71x | 55.2% | $7.5B |
| 3 | Liquidia Technologies IncLQDA | 71.0% | 26.6% | 1.67x | 30.7% | $2.6B |
| 4 | IDEXX Laboratories IncIDXX | 70.7% | 33.1% | 1.13x | 25.0% | $42.2B |
| 5 | Novo Nordisk A/SNVO | 52.8% | 18.9% | 1.80x | 33.1% | $161.1B |
| 6 | Aurinia Pharmaceuticals IncAUPH | 51.1% | 39.6% | 0.29x | 100.8% | $2.1B |
| 7 | Exelixis IncEXEL | 46.7% | 34.5% | 0.35x | 35.3% | $14.3B |
| 8 | argenx NV ADRARGX | 43.5% | 39.8% | 0.09x | 30.4% | $50.6B |
| 9 | ADMA Biologics IncADMA | 41.4% | 24.7% | 0.68x | 33.0% | $2.4B |
| 10 | DexCom IncDXCM | 38.1% | 15.5% | 1.46x | 20.1% | $39.6B |
| 11 | Novartis AG ADRNVS | 33.3% | 13.4% | 1.48x | — | $275.6B |
| 12 | Chemed CorpCHE | 33.1% | 17.4% | 0.90x | 10.6% | $6.8B |
| 13 | Hinge Health, Inc.HNGE | 31.7% | 13.2% | 1.40x | 15.2% | $8.1B |
| 14 | Solventum Corp.SOLV | 29.9% | 10.1% | 1.97x | 17.3% | $15.5B |
| 15 | TransMedics Group IncTMDX | 29.3% | 10.4% | 1.83x | 22.7% | $3.0B |
| 16 | ACADIA Pharmaceuticals IncACAD | 29.1% | 21.8% | 0.33x | 33.4% | $3.3B |
| 17 | Illumina IncILMN | 29.1% | 12.4% | 1.34x | 18.4% | $41.1B |
| 18 | Innoviva IncINVA | 29.0% | 21.0% | 0.38x | 81.2% | $1.5B |
| 19 | Insulet CorporationPODD | 26.4% | 11.9% | 1.23x | 12.3% | $9.7B |
| 20 | CareDx IncCDNA | 26.1% | 20.8% | 0.25x | 24.2% | $3.2B |
| 21 | Incyte CorporationINCY | 25.5% | 19.5% | 0.31x | 26.7% | $21.8B |
| 22 | Genmab ASGMAB | 25.3% | 20.3% | 0.25x | 36.4% | $22.0B |
| 23 | Johnson & JohnsonJNJ | 24.8% | 10.5% | 1.37x | 21.5% | $632.9B |
| 24 | Encompass Health CorpEHC | 23.9% | 8.3% | 1.54x | 10.0% | $11.9B |
| 25 | Healthcare Services Group IncHCSG | 23.7% | 15.0% | 0.58x | 6.6% | $1.4B |
| 26 | ResMed IncRMD | 23.1% | 17.0% | 0.36x | 26.9% | $34.4B |
| 27 | AstraZeneca PLCAZN | 22.9% | 9.1% | 1.51x | 17.4% | $238.8B |
| 28 | Iradimed CoIRMD | 22.7% | 20.1% | 0.13x | 26.7% | $1.1B |
| 29 | Vertex Pharmaceuticals IncVRTX | 21.8% | 16.1% | 0.35x | 35.0% | $123.0B |
| 30 | Lantheus Holdings IncLNTH | 21.0% | 11.4% | 0.84x | 17.7% | $6.3B |
| 31 | United Therapeutics CorporationUTHR | 20.5% | 18.2% | 0.13x | 41.6% | $22.8B |
| 32 | Ligand Pharmaceuticals IncorporatedLGND | 20.4% | 9.0% | 1.26x | 67.9% | $6.1B |
| 33 | Universal Health Services IncUHS | 20.3% | 9.6% | 1.11x | 8.4% | $10.4B |
| 34 | Mednax IncMD | 19.8% | 8.2% | 1.42x | 9.0% | $2.0B |
| 35 | Agilent Technologies IncA | 19.6% | 10.3% | 0.90x | 19.5% | $47.8B |
| 36 | Neurocrine Biosciences IncNBIX | 19.1% | 13.2% | 0.45x | 20.9% | $14.0B |
| 37 | West Pharmaceutical Services IncWST | 18.9% | 13.9% | 0.36x | 17.0% | $26.0B |
| 38 | Doximity IncDOCS | 18.2% | 15.4% | 0.18x | 25.5% | $4.7B |
| 39 | Harmony Biosciences HoldingsHRMY | 18.1% | 13.2% | 0.37x | 18.9% | $2.4B |
| 40 | ANI Pharmaceuticals IncANIP | 18.1% | 7.2% | 1.50x | 11.1% | $1.6B |
| 41 | BrightSpring Health Services, Inc. Common StockBTSG | 17.9% | 6.1% | 1.92x | 2.5% | $12.7B |
| 42 | Krystal Biotech IncKRYS | 17.8% | 16.1% | 0.10x | 54.8% | $9.3B |
| 43 | Caris Life Sciences, Inc. Common StockCAI | 17.8% | 8.6% | 1.08x | 10.6% | $8.9B |
| 44 | Progyny IncPGNY | 17.4% | 11.0% | 0.58x | 6.0% | $2.4B |
| 45 | Intuitive Surgical IncISRG | 17.3% | 15.0% | 0.14x | 28.4% | $153.4B |
| 46 | Dr. Reddy’s Laboratories Ltd ADRRDY | 17.0% | 11.5% | 0.47x | 17.4% | $10.9B |
| 47 | Inspire Medical Systems IncINSP | 16.4% | 14.6% | 0.12x | 15.0% | $2.1B |
| 48 | UFP Technologies IncUFPT | 15.6% | 10.6% | 0.47x | 11.4% | $2.3B |
| 49 | LeMaitre Vascular IncLMAT | 15.6% | 10.2% | 0.52x | 25.0% | $1.9B |
| 50 | Stryker CorporationSYK | 15.6% | 7.8% | 1.00x | 14.4% | $111.8B |
Ranked from each company's latest price and reported results. Companies need a page on Investingly (SEC statements on file). Open any company for its reverse DCF, insider buying and 13F holders.
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Questions
Which company ranks first on the highest return on equity healthcare stocks list?
HUTCHMED DRC (HCM), with a roe of 158.6%, as of October 12, 2026.
How is this list built?
Net income as a share of shareholders' equity, for companies worth over $1 billion with debt under twice equity (heavy debt inflates ROE). It shows the top 50 and is rebuilt every day.
Prices and ratios as of Oct 11, 2026. Statements from SEC filings. Information only, not investment advice.